Since the inception of the Sri Sathya Sai College for Women in Anantapur in 1968 and the Sri Sathya Sai College for Men at Brindavan in 1971 and the subsequent formation of the Sri Sathya Sai Higher Secondary School and Sri Sathya Sai Institute of Higher Learning in 1981, over 20,000 alumni have graduated from the portals of the University. These Alumni, while being professionally engaged in different parts of the world, continue to maintain their link with the University and are contributing substantially to society. The Alumni participate in various service activities in the field of Integral Education, Medicine, Village Upliftment (Grama Seva) and other areas.

Alumni professionally work as academicians, doctors, nurses, paramedical professionals, engineers, scientists, lawyers, chartered accountants, businessmen, management professionals, administrators (Indian Administrative Service), artists, musicians, dancers, agriculturists, consultants, airline pilots, state and central government employees, personnel in the armed forces and the merchant navy.